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The toxin by itself is launched within the bacterium as an individual chain, then results in being activated when cleaved by its very own proteases.[43] The active variety is made up of a two-chain protein made up of a one hundred-kDa major chain polypeptide joined by way of disulfide bond into a fifty-kDa mild chain polypeptide.[92] The hefty chai
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Complications with BoNT use in ophthalmology occur due to toxin diffusion or inadvertent placement into the adjacent muscles. Ptosis of the eyelid is the most typical complication of BoNT treatment of strabismus and blepharospasms.23 Even though this outcome is nearly always momentary and self-resolving, apraclonidine 0.5% (Iopidine) or phenylepher